Brand new in box. Skin Medica Retinol Complex 1.0 1 fl oz. Key Benefits Enhances skin tone, texture, and resiliency Diminishes appearance of fine lines and coarse wrinkles Encapsulated with PhytoShield™ Complex, an antioxidant complex, enhancing skin texture and minimizing irritation How to use: Apply In the evening after cleansing and toning and before applying your moisturizer. If a retinol product has never been used before, begin twice a week 2-3 days apart, gradually increasing frequency to every other night, and then advancing to each evening or as tolerated. Where to Apply Apply to entire face. Avoid getting in eyes. If contact occurs, rinse eyes thoroughly with water.