Our award-winning R45® The Reversal anti-aging retinol night cream utilizes a patented booster system that is so powerful, you only need to use it twice a year. In just 45 days, this 3-phase treatment is clinically proven to repair all 4 benchmarks of aging – discoloration, wrinkles, enlarged pores and uneven texture. Our proprietary retinol complex, TriGLO™, mimics the skin-smoothing effects of clinical retinol without the harsh side effects. Finally, a retinol every skin type can use. brand new I'm box, never used!